Develops and manufactures calcium compounds and specialty polymers for infection management in bone and soft tissue

Biocomposites Ltd.

Keele (UK) · Rostock · Munich · Wilmington, NC (USA) · Shanghai · New Delhi · Buenos Aires · São Paulo · Prato · ChamberetNew on Amplifa

1997Founded (MBO of a ceramics company)

550+Employees in 11 countries

1.4 million units/yearManufacturing capacity (cleanrooms UK, Germany, Argentina)

100+Countries sold in

1 million+Procedures per year using Biocomposites products

About Biocomposites

Biocomposites is an international medical device company headquartered in Keele (Staffordshire, UK) that develops, manufactures and markets products for infection management in bone and soft tissue. The company specializes in innovative calcium compounds and medical specialty polymers for surgical use; the product portfolio includes antibiotic-eluting calcium sulfate carriers (STIMULAN), bone substitute materials based on calcium phosphate and hydroxylapatite (genex, NanoBone), polymer composites (Bilok, Biosteon) as well as bone cement and antibiotic-eluting spacers (SYNICEM). Manufacturing takes place in purpose-built cleanrooms in the UK, Germany and Argentina with a capacity of around 1.4 million units per year; quality assurance, processing, testing and distribution are fully in-house. The products are used in the specialty areas of musculoskeletal infection, orthopedics, traumatology, spine surgery, foot and ankle, podiatry and sports injuries, in over 1 million procedures annually and sold in more than 100 countries. With over 550 employees in 11 countries, Biocomposites maintains subsidiaries including in the USA, China, India, Brazil, Argentina, France, Italy and Germany (Munich, Rostock).

Site: ST5 5NL Keele, Staffordshire
Processes: Manufacturing of calcium compounds and specialty polymer medical devices (engineering, manufactures, Manufacturing in purpose-built cleanrooms (1.4 million units/year), Manufacturing of bone cement and antibiotic-eluting spacers (SYNICEM spacers & bone cement), Manufacturing of bone substitute materials (genex, NanoBone, STIMULAN, Allogran-R, Biosteon), Quality assurance: manufacturing, processing, testing and distribution in-house, Engineering and manufacturing of medical devices (calcium compounds and specialty polymers), Manufacturing in cleanrooms in the UK, Germany and Argentina, In-house quality assurance, processing, testing and distribution
Materials: Calcium sulfate (truly absorbable, recrystallized; STIMULAN), Calcium phosphate composite (osteoconductive, genex), Beta-tricalcium phosphate/calcium sulfate (geneX injectable), Nanocrystalline hydroxylapatite in silica gel matrix (NH-SiO2, NanoBone), Medical polymer composites (specialty polymers, Bilok, Biosteon; carbon fiber reinforced polymer, Acrylic bone cement (SYNICEM bone cement), Calcium sulfate (recrystallized, fully resorbable), Calcium phosphate composite
Certificates: AdvaMed Code of Ethics certification, AdvaMed Code of Ethics, ISO 9001, ISO 13485
Founded: 1997
Employees: 550+
Industries: Medical technology, Orthopedics, Traumatology, Spine surgery, Foot & ankle surgery, Podiatry

01
R&D and product development
02
Manufacturing of calcium compounds and specialty polymers in cleanrooms
03
Processing and testing (in-house)
04
Quality assurance
05
Worldwide distribution via own subsidiaries

Materials & Processes

CaSO4

Calcium sulfate (recrystallized, fully resorbable)

Basis of STIMULAN as an antibiotic-eluting carrier for bone and soft tissue infections.

CaP

Calcium phosphate composite

Osteoconductive bone substitute material of the genex product family.

β-TCP/CaSO4

Beta-tricalcium phosphate/calcium sulfate

Injectable bone augmentation in genex for contained defects, among others after curettage of benign bone tumors.

NH-SiO2

Nanocrystalline hydroxylapatite in silica gel matrix

Material of NanoBone, enables neovascularization during bone growth.

PKM

Medical polymer composites (specialty polymers)

Used in Bilok and Biosteon as well as carbon fiber-reinforced polymer cages.

PMMA

Acrylic bone cement

Basis of SYNICEM bone cement and antibiotic-eluting spacers.

Locations

Keele

Headquarters, cleanroom production, R&D

Lot size: High-volume production (1.4 million units/year total)
Materials: Calcium sulfate, calcium phosphate, polymers, acrylic bone cement

Cleanroom manufacturing

Rostock

Site/subsidiary (Biocomposites GmbH, NanoBone/Artoss)

Materials: Nanocrystalline hydroxylapatite in silica gel matrix

Munich

Sales (Biocomposites Deutschland GmbH)

Wilmington, NC

Sales (Biocomposites Inc.)

Shanghai

Sales (Biocomposites Shanghai Ltd.)

New Delhi

Sales (Biocomposites India Pvt. Ltd.)

Buenos Aires

Sales/production Subiton Laboratorios (bone cement & spacer)

Materials: Acrylic bone cement

São Paulo

Sales (Biocomposites Ltda.)

Prato

Sales (Biocomposites S.R.L.)

Chamberet

Sales (Synimed)

Products & Components

**STIMULAN beads (antibiotic-eluting calcium sulfate beads)**Calcium sulfate carrier · Musculoskeletal infection

**genex injectable bone substitute material**β-TCP/calcium sulfate · Traumatology

**NanoBone SBX**Hydroxylapatite/silica gel · Spine surgery

**NanoBone QD**Hydroxylapatite/silica gel · Orthopedic reconstruction

**genex ds putty**Calcium phosphate composite · Traumatology

Inside the production

Focus on calcium compounds and specialty polymers

Product development at the Keele headquarters

Industries

Medical technologyOrthopedicsTraumatologySpine surgeryFoot & ankle surgeryPodiatrySports injuriesWound and infection managementWound management / infection management in bone and soft tissue

Processes & technical limits

Processes	Tolerance	Max. part	Weight	Lot size	Materials
Manufacturing of calcium compounds and specialty polymer medical devices (engineering, manufacturesPlastics	–	–	–	–	calcium sulfate, calcium phosphate, hydroxylapatite, medical polymers, acrylic bone cement (PMMA)
Manufacturing in purpose-built cleanrooms (1.4 million units/year)Assembly	–	–	–	1.4 million units per year	calcium sulfate, calcium phosphate, polymers
Manufacturing of bone cement and antibiotic-eluting spacers (SYNICEM spacers & bone cement)Plastics	–	–	–	–	acrylic bone cement
Manufacturing of bone substitute materials (genex, NanoBone, STIMULAN, Allogran-R, Biosteon)Plastics	–	–	–	–	calcium sulfate, beta-tricalcium phosphate/calcium sulfate composite, nanocrystalline hydroxylapatite in silica gel matrix, calcium phosphate composite
Quality assurance: manufacturing, processing, testing and distribution in-houseTesting	–	–	–	–	–

Additional services

Engineering and manufacturing of medical devices (calcium compounds and specialty polymers)Manufacturing in cleanrooms in the UK, Germany and ArgentinaIn-house quality assurance, processing, testing and distributionR&D with ongoing FDA studies (STIMULAN VG, Phase II)

Quality & Certificates

Quality assurance, processing, testing and distribution are carried out entirely in-house to ensure reliable, predictable and reproducible clinical performance. The processes meet and exceed medical standards along the entire value chain.

Evidence	Keele
AdvaMed Code of Ethics
ISO 9001
ISO 13485

History

1987
Founder researched the potential of traditional ceramics in orthopedics
1997
Management buy-out of a ceramics company; founding of Biocomposites Ltd., Staffordshire, UK
1998
Launch of Bilok and STIMULAN Pellets
1999
Launch of FORTOSS and Allogran-R
2000
Founding of Biocomposites Inc., Wilmington NC, USA
2001
Launch of STIMULAN Kit and Biosteon
2002
Launch of genex
2003
Founding of Biocomposites (Shanghai) Ltd., China
2004
Move to purpose-built headquarters in Keele, Staffordshire
2007
Launch of genex putty
2009
Launch of genex ds
2010
Presence in Canada established
Launch of STIMULAN Rapid Cure
Two Queen's Awards for Enterprise: Innovation and International Trade
Acquisition of Artoss GmbH (NanoBone) and Subiton/SYNIMED (bone cement & spacer)
EU MDR approval for STIMULAN
2025
'Most Innovative Product' for STIMULAN at the JWC Awards 2025
2026
Biocomposites named in The Sunday Times 100 Tech 2026