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BRIEM – Fertigung

BRIEM manufactures measuring instruments and monitoring systems for cleanrooms, laboratories and HVAC applications.

BRIEM Logo

BRIEM Steuerungstechnik GmbH

Nürtingen · Berlin · GevelsbergNew on Amplifa

1977Founded
more than 50Employees
3Locations in Germany
HRB 224325, Amtsgericht StuttgartCommercial register entry
more than 400Customers in monitoring

We are BRIEM

BRIEM Steuerungstechnik GmbH develops and produces measuring instruments and monitoring solutions for cleanrooms, laboratories and HVAC applications. The product range includes analogue and digital differential pressure gauges, combination instruments for pressure, temperature and humidity, cleanroom panels, particle counters, pressure measuring probes and accessories. With the BRIEM Monitoring System, relevant environmental and process parameters such as room pressure, temperature, humidity and particle concentration (0.1 µm to 10 µm) are measured, monitored, alarmed and documented without gaps. The service portfolio ranges from consulting, planning, installation and commissioning through qualification and temperature mapping (GDP/GxP) to calibration service (traceable, DAkkS/DKD), maintenance and retrofit. Founded in 1977 in Filderstadt, the Swabian family-owned company today employs more than 50 staff at its headquarters in Nürtingen as well as in Berlin and Gevelsberg. Customers come from the pharmaceutical industry, medical technology, semiconductor production, hospitals, pharmacies, blood banks and research laboratories.

Site
Nürtingen
Processes
Filter monitoring with differential pressure gauges (filter monitors), Temperature mapping / storage mapping (GDP/GxP) with real-time technology and 3D visualisation, Calibration service (traceable DAkkS/DKD calibration, in the laboratory and on site), Installation and commissioning of monitoring systems, Qualification (qualification plans and reports, GMP), Maintenance and support for monitoring systems, Consulting and planning of monitoring projects, Airlock/door control for cleanrooms
Materials
Stainless steel, PU (polyurethane) measuring hose, P.O.M. white plastic (pressure probes), Brass tube (measuring probe), Neoprene (ferrules), Glycerine (reference body), Propylene glycol (reference body), Polyoxymethylene (POM, reference body)
Certificates
Traceable calibration (DAkkS/DKD), GMP-trained service technician team, FAT test centre, GAMP 5 validated software
Founded
1977
Employees
more than 50
Industries
Pharmaceutical industry, Medical technology, Semiconductor/microchip production, Hospitals and pharmacies, Blood banks/transfusion medicine, Laboratories (BSL3/BSL4, sterile laboratories)
  1. 01

    Consulting and planning

  2. 02

    In-house development of measuring instruments and software

  3. 03

    Control cabinet construction and production (Plant 2 Nürtingen)

  4. 04

    FAT testing in the test centre

  5. 05

    Installation and commissioning

  6. 06

    Qualification and temperature mapping (GDP/GxP)

  7. 07

    Calibration service (traceable, DAkkS/DKD)

  8. 08

    Maintenance, support and retrofit

Materials and measuring methods

1.4301

Stainless steel

Used for pressure measuring probes and instrument front panels in the cleanroom and ventilation sector.

POM

Polyoxymethylene (P.O.M.) white plastic

Material for pressure measuring probes and reference bodies.

PU

PU (polyurethane) measuring hose

Thick-walled, stable measuring hose for pressure-resistant measuring setups.

Ms

Brass tube

Material for measuring probes when retrofitting filter monitoring systems.

Al

Aluminium

Used for reference bodies and accessory components.

Gly

Glycerine / propylene glycol

Filling media for reference bodies used to monitor blood supplies.

Locations

Standort Nürtingen

Nürtingen

DE

Headquarters, production, FAT test centre, calibration laboratory

Lot size
Individual projects to large volumes from stock
Materials
Stainless steel 1.4301, plastic, brass, aluminium, neoprene
  • FAT test centre (Plant 2)
  • Control cabinet construction
  • Calibration laboratory with DAkkS/DKD-certified measuring equipment

Berlin

DE

Branch office, on-site service

Gevelsberg (Hagen)

DE

Branch office, on-site service

Products and components

Differential pressure gauge GB 604
Differential pressure gauge GB 604Capacitive stainless steel measuring cell · HVAC
Combination instrument pressure/temperature/humidity GBD 604 + 281
Combination instrument pressure/temperature/humidity GBD 604 + 281In-house production · Cleanroom/laboratory environment
LDPC particle counter
LDPC particle counterParticle monitoring · Cleanroom monitoring
Mobile particle counter
Mobile particle counterParticle monitoring · Laboratory and cleanroom
Cleanroom information centre
Cleanroom information centreIn-house development · Cleanroom monitoring
Cleanroom signal light
Cleanroom signal lightSignalling · Cleanroom monitoring
Combination panel
Combination panelField device · Cleanroom monitoring
Differential pressure gauge Magnehelic M2000
Differential pressure gauge Magnehelic M2000Analogue measurement technology · Filter monitoring
Differential pressure gauge MD201 with switch contact
Differential pressure gauge MD201 with switch contactAnalogue measurement technology · Filter monitoring
Room pressure probe
Room pressure probeIn-house production · Cleanroom
Measuring probe TSS 82
Measuring probe TSS 82Probe technology · Temperature measurement

Inside the production

BRIEM cleanroom monitoring system
BRIEM cleanroom monitoring system
Measuring instruments for HVAC applications
Measuring instruments for HVAC applications
Retrofit – modernisation of a cleanroom monitoring system
Retrofit – modernisation of a cleanroom monitoring system
Data analysis, trending and reporting according to Annex 1
Data analysis, trending and reporting according to Annex 1
Differential pressure gauges for filter monitoring
Differential pressure gauges for filter monitoring
BRIEM LIVE – cleanroom monitoring week
BRIEM LIVE – cleanroom monitoring week

Industries

Pharmaceutical industryMedical technologySemiconductor/microchip productionHospitals and pharmaciesBlood banks/transfusion medicineLaboratories (BSL3/BSL4, sterile laboratories)Radionuclide laboratoriesVeterinary pharmaceuticalsResearch and drug developmentHVAC technologyHospitals/pharmacies

Processes & technical limits

ProcessesToleranceMax. partWeightLot sizeMaterials
Testing––––Stainless steel 1.4301, P.O.M. plastic, PU
Filter monitoring with differential pressure gauges (filter monitors)Testing–––large volumes from stock–
Temperature mapping / storage mapping (GDP/GxP) with real-time technology and 3D visualisationTesting–––––
Calibration service (traceable DAkkS/DKD calibration, in the laboratory and on site)Testing–––––
Installation and commissioning of monitoring systemsAssembly–––––
Qualification (qualification plans and reports, GMP)Testing–––––
Maintenance and support for monitoring systemsAssembly–––––
Consulting and planning of monitoring projectsEngineering–––––
Airlock/door control for cleanroomsAssembly–––––
Retrofit / system modernisation of GMP monitoring systemsAssembly–––––
Particle monitoring (particle counters 0.1 µm – 10 µm)Testing–––––
In-house development and production of measuring instruments as well as control cabinet constructionEngineering––––Stainless steel 1.4301, Plastic, Brass, Neoprene, Aluminium

3 Anlagen & Maschinen

MachineManufacturer / modelQuantityWorking areaYear builtSite
FAT test centre (Plant 2)–––2012Nürtingen
Control cabinet construction (production area)–––2012Nürtingen (Plant 2)
Calibration laboratory with DKD/DAkkS-certified measuring equipment––––Nürtingen

Additional services

Consulting and planningInstallation and commissioningQualification (qualification plans and reports)Calibration service (traceable, DAkkS/DKD)Maintenance and supportTemperature mapping (GDP/GxP)Retrofit/system modernisationAirlock/door controlParticle monitoringCustom solutions/adaptation

Reference customers

Schlehen-ApothekeUniversitätsklinikum TübingenBA.UnternehmensgruppeArtivion Inc., Jotec GmbHUniklinikum SaarlandMedipolis Produktion GmbH

Quality and calibration

Calibration is performed traceably to national standards (DAkkS/DKD) in our own calibration laboratory and on site. GMP-trained service technicians and qualification engineers prepare qualification plans and reports; the monitoring software is GAMP 5 validated.

EvidenceNürtingenBerlinGevelsberg (Hagen)
Traceable calibration (DAkkS/DKD)
GMP-trained service technician team
FAT test centre
GAMP 5 validated software

Milestones of our company history

  1. 1977

    Gerhard Briem founds BRIEM Steuerungstechnik GmbH in Filderstadt

  2. 1991

    Jochen Briem joins the company, first digital displays

  3. 1999

    Company headquarters moved to Nürtingen

  4. 2000

    First laboratory and cleanroom technology projects

  5. 2006

    First cleanroom monitoring projects

  6. 2010

    Extension of the company's main building

  7. 2012

    Development department and control cabinet construction in Plant 2 Nürtingen, FAT test centre

  8. 2013

    Opening of the Berlin branch office

  9. 2017

    40 years of BRIEM

  10. 2019

    Opening of the Hagen (Gevelsberg) branch office

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