Development and production of magnetic nano- and microparticles for bioseparation, gene transfection and detection in the life sciences.

chemicell GmbH

BerlinNew on Amplifa

BerlinHead office

HRB 76663, Amtsgericht Berlin-CharlottenCommercial register

GmbHLegal form

About chemicell

chemicell GmbH, based in Berlin, develops and produces systems based on magnetic nano- and microparticles for applications in bioseparation, gene transfection and detection. The portfolio includes, among others, the product lines SiMAG, fluidMAG, nano-screenMAG and ZeoliteMAG as well as fluorescent microspheres (screenCORE, beadBALL) and the Magnetofection™ reagents PolyMAG and CombiMAG. A focus lies on ready-to-use kits, in particular DNA and RNA purification kits, which are compatible with laboratory automation platforms such as KingFisher™ 96 and BioSprint™ 96. The particles consist of superparamagnetic magnetite cores with different matrices and surface functionalizations, including silicon dioxide, zeolite, PEG, chitosan, polyvinyl alcohol and lipids. The products are intended for research applications only. The company is open to cooperation with other companies and scientific institutes and distributes its products worldwide via distributors.

Site: Berlin
Processes: Production of magnetic nano- and microparticles (bioseparation, Magnetofection, magnetic beads,, Magnetofection (magnetic gene transfection) with the reagents PolyMAG and CombiMAG for nucleic acid, DNA and RNA purification kits (e.g. MagnetoPURE-Macro) compatible with laboratory automation, Development and production of magnetic nano- and microparticles, Bioseparation, Gene transfection (Magnetofection™), Detection systems, Ready-to-use kits compatible with laboratory automation (e.g. KingFisher™ 96, BioSprint™ 96)
Materials: Magnetite (superparamagnetic iron oxide, particle core), Silicon dioxide (silica matrix for microspheres and SiMAG particles), Zeolite (aluminosilicate matrix, ZeoliteMAG), Polyvinyl chloride (beadBALL microspheres), Polystyrene (reference microspheres), Polyethylene glycol (PEG/PEG-amine derivatives, fluidMAG-PEG/Amine), Chitosan (fluidMAG/nano-screenMAG chitosan), Polyvinyl alcohol (fluidMAG-PVA)
Industries: Biotechnology, Life Sciences / Molecular Biology, Research and Diagnostics (research applications only)

01
Development of particle formulations and surface chemistry
02
Synthesis of superparamagnetic magnetite nano- and microparticles
03
Coating/functionalization with matrices (silica, zeolite, polymers, lipids)
04
Coupling of ligands (proteins, antibodies, biotin, oligo(dT), etc.)
05
Configuration into ready-to-use kits and reagents
06
Distribution via direct contact and distributors

Materials and Functionalizations

Fe3O4

Magnetite (superparamagnetic iron oxide)

Particle core of all magnetic nano- and microparticles.

SiO2

Silicon dioxide (silica matrix)

Inert, stable, autoclavable matrix for SiMAG particles and screenCORE microspheres.

Zeolith

Zeolite (aluminosilicate)

Highly porous, anionically charged matrix in ZeoliteMAG used as a cation exchanger.

PVC

Polyvinyl chloride

Mechanically and chemically stable matrix of the beadBALL microspheres.

Polystyrene

Matrix for reference microspheres.

PEG

Polyethylene glycol (PEG/PEG-amine)

Enables covalent coupling to carboxyl groups of peptides and proteins and improves protein stability.

Chitosan

Surface coating of the fluidMAG and nano-screenMAG chitosan particles.

PVA

Polyvinyl alcohol

Coating matrix of the fluidMAG-PVA particles.

Lipid

Lipids

Coating of the fluidMAG-Lipid particles.

mHPA

Hydroxyapatite

Matrix of the magnetic hydroxyapatite (mHPA).

PolyMAG/CombiMAG

Magnetofection™ reagents

Magnetic particle preparations for the transfection of plasmid DNA, antisense oligonucleotides, siRNA as well as adeno- and retroviruses.

Locations

Berlin

Head office, development and production

Materials: Magnetite, silicon dioxide, zeolite, polymers

Products

**MagnetoPURE-Macro DNA Purification Kit**Magnetic bioseparation · Laboratory automation (KingFisher™ 96 / BioSprint™ 96)

**Magnetofection™ reagents (PolyMAG, CombiMAG)**Gene transfection · Research

**nano-screenMAG fluorescent magnetic nanoparticles**Fluorescence detection · Life sciences

**screenCORE-Amine fluorescent microspheres (1 µm, silica)**Microspheres · Detection

**fluidMAG-PEG/Amine magnetic nanoparticles**Bioseparation · Life sciences

Inside the production

Industries

BiotechnologyLife Sciences / Molecular BiologyResearch and Diagnostics (research applications only)

Processes & technical limits

Processes	Tolerance	Max. part	Weight	Lot size	Materials
Production of magnetic nano- and microparticles (bioseparation, Magnetofection, magnetic beads,Engineering	–	–	–	–	Magnetite, Silicon dioxide (silica), Zeolite, Polyvinyl chloride, Polystyrene, PEG, Polymers
Magnetofection (magnetic gene transfection) with the reagents PolyMAG and CombiMAG for nucleic acidEngineering	–	–	–	–	Plasmid DNA, Antisense oligonucleotides, siRNA, Adenovirus, Retrovirus
DNA and RNA purification kits (e.g. MagnetoPURE-Macro) compatible with laboratory automationEngineering	–	–	–	–	–

Additional services

Development and production of magnetic nano- and microparticlesBioseparationGene transfection (Magnetofection™)Detection systemsReady-to-use kits compatible with laboratory automation (e.g. KingFisher™ 96, BioSprint™ 96)DNA and RNA purification kits