Develops and delivers continuous chromatography systems (Contichrom®) for biopharmaceutical purification.
ChromaCon AG
Zurich (Technoparkstrasse 1, 8005)New on Amplifa
About ChromaCon
ChromaCon AG, headquartered in Zurich, specializes in continuous preparative chromatography. The company develops and markets the Contichrom® system platform (in collaboration with YMC) for the purification of peptides, oligonucleotides, monoclonal antibodies, antibody-drug conjugates (ADCs), recombinant proteins, viral vectors (AAV), as well as small molecules and nutraceuticals. Core technologies are MCSGP (Multicolumn Countercurrent Solvent Gradient Purification) with UV-based process control AutoPeak®, continuous capture chromatography CaptureSMB® with AutomAb®, multi-dimensional chromatography (2D/3D) with ChromIQ®, and N-Rich® for automated enrichment of trace impurities. The portfolio ranges from the Contichrom® CUBE benchtop FPLC system for process development, through the PILOT system for clinical GMP, to industrial TWIN-HPLC and sanitary GMP LPLC systems for commercial production. In addition, ChromaCon offers demos, training, process modeling, system rental and feasibility studies, as well as support for scale-up, process characterization and Process Performance Qualification (PPQ).
- Site
- Zurich
- Processes
- MCSGP continuous chromatography (Multicolumn Countercurrent Solvent Gradient Purification), CaptureSMB® continuous capture chromatography with AutomAb®, Multi-dimensional chromatography (2D/3D) with ChromIQ®, N-Rich® continuous enrichment of trace impurities (impurity isolation), Process modeling (mechanistic models for batch, MCSGP, CaptureSMB®), Process characterization and Process Performance Qualification (PPQ) for MCSGP, Process development support (demos, training, consulting), Process modeling
- Materials
- Peptides (synthetic, e.g. bivalirudin), Oligonucleotides, Monoclonal antibodies (mAbs), Antibody-drug conjugates (ADCs), Recombinant proteins, Viral vectors (AAV), Small molecules & nutraceuticals, MCSGP with AutoPeak®
- Industries
- Pharmaceutical biotechnology, Peptide manufacturing, Oligonucleotide manufacturing, mAbs/ADCs, Viral vectors (AAV), Small molecules & nutraceuticals
- 01
Process development (demos, feasibility studies)
- 02
Process modeling
- 03
Scale-up to pilot and production systems
- 04
Process characterization & PPQ support
- 05
Training, maintenance & system rental
Applications & Target Molecules
MCSGP with AutoPeak®
Continuous two-column polishing chromatography for peptides and oligonucleotides; breaks the yield-purity trade-off through internal recirculation of side fractions.
CaptureSMB® with AutomAb®
Continuous capture chromatography for mAbs, ADCs, AAV and recombinant proteins with dynamic breakthrough control and reduced resin/buffer consumption.
Multi-Dimensional Chromatography (2D/3D)
Automated sequential purification across multiple columns and chemistries in a single run, controlled by ChromIQ®.
N-Rich® Impurity Isolation
Automated on-column enrichment of trace impurities, replacing weeks of manual fraction collection with an unattended run.
AutoPeak® / AutomAb® Process Control
UV-based real-time process analytics (PAT) that automatically adapts the continuous process to feed and column variability.
Locations
Zurich
CHHeadquarters
- Contichrom® CUBE (benchtop FPLC, 100 bar)
- Contichrom® PILOT (preparative HPLC, 100 bar, up to 300 mL/min)
- Contichrom® TWIN HPLC (industrial, 80 bar, up to 36 L/min)
- Contichrom® TWIN LPLC – Capture (sanitary GMP system)
- Contichrom® TWIN LPLC – Polishing (sanitary GMP system)
Systems & Technologies
Inside the production
Industries
Processes & technical limits
| Processes | Tolerance | Max. part | Weight | Lot size | Materials |
|---|---|---|---|---|---|
| MCSGP continuous chromatography (Multicolumn Countercurrent Solvent Gradient Purification)Engineering | – | – | – | – | Peptides, Oligonucleotides, Antibody-drug conjugates (ADCs), Recombinant proteins |
| CaptureSMB® continuous capture chromatography with AutomAb®Engineering | – | – | – | – | mAbs, Antibody variants, Viral vectors (AAV), ADCs, Recombinant proteins |
| Multi-dimensional chromatography (2D/3D) with ChromIQ®Engineering | – | – | – | – | – |
| N-Rich® continuous enrichment of trace impurities (impurity isolation)Engineering | – | – | – | – | – |
| Process modeling (mechanistic models for batch, MCSGP, CaptureSMB®)Engineering | – | – | – | – | – |
| Process characterization and Process Performance Qualification (PPQ) for MCSGPEngineering | – | – | – | – | Synthetic bivalirudin |
5 Anlagen & Maschinen
| Machine | Manufacturer / model | Quantity | Working area | Year built | Site |
|---|---|---|---|---|---|
| Benchtop FPLC system (100 bar) for process development | ChromaCon (YMC) Contichrom® CUBE | – | – | – | – |
| Preparative HPLC (100 bar) for pilot/clinical GMP | ChromaCon (YMC) Contichrom® PILOT | – | Flow rates up to 300 mL/min | – | – |
| Industrial HPLC (80 bar) for GMP production | ChromaCon (YMC) Contichrom® TWIN HPLC | – | Flow rates up to 36 L/min | – | – |
| Sanitary GMP LPLC capture system | ChromaCon (YMC) Contichrom® TWIN LPLC – Capture | – | – | – | – |
| Sanitary GMP LPLC polishing system | ChromaCon (YMC) Contichrom® TWIN LPLC – Polishing | – | – | – | – |
Additional services
Reference customers