Development of an adaptive, neuromorphic pacemaker for the treatment of heart failure and arrhythmias
CResPulse – Konsortium (University of Bath, Medical University of Vienna, ICRC Brno)
Bath (UK) · Vienna (AT) · Brno (CZ)New on Amplifa
About CResPulse
CResPulse is a university pre-spinout consortium, consisting of the University of Bath (UK), the Medical University of Vienna (Austria), and the International Clinical Research Center (ICRC) at St. Anne's University Hospital in Brno (Czech Republic). The project is funded within the framework of the European Union's EIC Transition Programme with up to 2.5 million Euros (Grant Agreement 101214165). The goal is the development of a neuromorph adaptively 3-electrode pacemaker (PM/CRT) that replicates the natural breathing rhythm synchronization of the heart using Central Pattern Generators (CPGs) on analog Neuromorphic Chips. The circuits are trained through nonlinear optimization (RPDA) and data assimilation using ECG, respiratory, and blood pressure data. The consortium is working on miniaturization, animal trials, and preparation for Phase 1 studies (TRL4 to TRL6), including ISO-13485 compliant manufacturing of the board and housing, as well as IP and business plan development.
- Site
- Bath (UK)
- Processes
- Development of an adaptive neuromorphic pacemaker (3-electrode PM/CRT), CPG modeling and nonlinear optimization (RPDA), Neuromorphic hardware integration, Animal trials (large animals) and acute in-vivo studies, Preparation of Phase-1 human trials (TRL4→TRL6), Business plan, IP strategy, ISO 13485 quality management (targeted)
- Materials
- Central Pattern Generator (neuromorphic circuit), Mixed-Signal Neuromorphic Chip, Nonlinear Programming/Data Assimilation
- Certificates
- ISO 13485 (targeted)
- Industries
- Medical Technology, Cardiology, Neuromorphic Engineering
- 01
Biology constraints-based modeling (CPG)
- 02
Nonlinear optimization and data assimilation (RPDA)
- 03
Hardware integration on Neuromorphic chips
- 04
Miniaturization of Board and Housing
- 05
In-vivo animal trials
- 06
Preparation of Phase-1 human trials
Technologies and Methods
Central Pattern Generator (neuromorphic circuit)
Electronic oscillators simulate the nonlinear dynamics of respiratory and cardiac neuronal circuits.
Mixed-Signal Neuromorphic Chip
Silicon neurons emulate membrane conductivities and synaptic dynamics in real-time with low power consumption.
Nonlinear Programming/Data Assimilation
Trains millions of parameters using ECG, respiratory, and blood pressure data for precise beat-to-beat stimulation.
Partner Sites
Bath
GBHardware development, manufacturing of board and housing
- Lot size
- Single items/Prototypes
- Materials
- Electronics, ISO-13485 housing
- Neuromorphic Chip Design
- VLSI Implementation
- Telemetry Module
- Optical Sensor
Vienna
ATClinical trials and ethical approval
Brno (ICRC)
CZPrototype tests, animal studies, impedance measurement
- Chest Impedance Measurement Module
- In-vivo Acute Studies Setup
Industries
Additional services
Quality and Certification
Targeting ISO-13485 conformity for manufacturing; the housing has already been manufactured according to ISO 13485. The goal is CE conformity and EMA requirements for Phase 1 studies.
| Evidence | Bath |
|---|---|
| ISO 13485 (targeted) |
Project and Research History
- 2016
ICRC was part of the predecessor project CResPace, which confirmed adaptive stimulation
- 2025
Start of the EIC Transition project CResPulse (reporting period 2025-06-01 to 2026-05-31, funding up to 2.5 Mio. EUR); beginning of prototype work at ICRC in summer 2025
- 2026
Ethical approval at MedUni Vienna (March); first acute in-vivo studies on resynchronization of 3 heart chambers; miniaturized board and ISO-13485 housing manufactured by University of Bath; 2 patents planned