Manufacturer of ShearJet® high-pressure homogenizers for high-shear processing from laboratory to production scale.
Dyhydromatics LLC
Maynard, MA, USANew on Amplifa
About Dyhydromatics
Dyhydromatics LLC is a US-based manufacturer of high-pressure homogenizers of the ShearJet® product family headquartered in Maynard, Massachusetts. The company designs and manufactures electro-hydraulic and pneumatic homogenizer systems for high-shear processing applications such as uniform particle size reduction down to the nanoscale, nanoemulsions, nanosuspensions, liposomes and cell disruption. The portfolio comprises four series — ShearJet® HL60 V2 (laboratory), PL300 (pneumatic benchtop type), HP350 V2 (R&D and pilot) and HP1200 V2 (pilot and production) — as well as Feed & Skid Systems for upstream and downstream process integration. In addition to equipment manufacturing, Dyhydromatics offers proof-of-concept testing, formulation development with experience from more than 1500 formulations, qualification support (FAT/SAT, IQ/OQ), and service and maintenance also for homogenizers from other manufacturers. Customer industries include pharmaceuticals, biotechnology, chemicals, personal care, food/nutraceuticals and cannabis. All systems are manufactured and tested in Maynard.
- Site
- Maynard, MA, USA
- Processes
- High-pressure homogenization (High-Shear Processing, particle size reduction down to nano,, Proof of Concept Testing (application-oriented formulation and process capability tests with, Formulation development (>1500 formulations, optimal process parameters), Qualification support (FAT/SAT, IQ/OQ, validation-ready systems, documented, Service & maintenance (spare parts, preventive maintenance, repairs for ShearJet® and other, Feed & Skid Systems (upstream/downstream process integration), Proof of Concept Testing, Service & Maintenance (also for homogenizers from other manufacturers)
- Materials
- ShearJet® HL60 V2, ShearJet® PL300, ShearJet® HP350 V2, ShearJet® HP1200 V2, High-Shear Processing
- Certificates
- FAT/SAT, IQ/OQ, Documented process control
- Founded
- 2015
- Industries
- Pharmaceutical Industry, Biotechnology, Chemical Industry, Personal Care / Cosmeceuticals, Food / Nutraceuticals, Cannabis
- 01
Design and Engineering
- 02
Manufacturing of ShearJet® systems
- 03
Testing in Maynard
- 04
Proof of Concept Testing
- 05
Formulation Development
- 06
Qualification Support (FAT/SAT, IQ/OQ)
- 07
Service & Maintenance
- 08
Feed & Skid Systems for Process Integration
Processes and Technologies
ShearJet® HL60 V2
Compact electro-hydraulic laboratory homogenizer for formulation development, nanoemulsions, liposomes and process optimization; now also available in 110 VAC.
ShearJet® PL300
Pneumatic benchtop homogenizer for medium volumes, formulation development and scale-up applications.
ShearJet® HP350 V2
Electro-hydraulic homogenizer for process development, pilot processing and increased batch capacity.
ShearJet® HP1200 V2
Electro-hydraulic homogenizer for larger batches, near-continuous throughput and pilot or small-series production.
High-Shear Processing
High-pressure homogenization for particle size reduction down to the nanoscale, nanoemulsions, nanosuspensions, liposomes and cell disruption.
Locations
Maynard, MA, USA
USHeadquarters, manufacturing and testing
- Lot size
- Laboratory (Small Volume) to production
- Materials
- Pharmaceutical formulations, biotech cell suspensions, chemicals, personal care, food/nutraceuticals
- ShearJet® HL60 V2
- ShearJet® PL300
- ShearJet® HP350 V2
- ShearJet® HP1200 V2
- Feed & Skid Systems
Industries
Processes & technical limits
| Processes | Tolerance | Max. part | Weight | Lot size | Materials |
|---|---|---|---|---|---|
| High-pressure homogenization (High-Shear Processing, particle size reduction down to nano,Engineering | – | – | – | Laboratory (Small Volume) – Production | Pharmaceutical formulations, Biotech cell suspensions, Chemicals, Personal Care / Cosmeceuticals, Food / Nutraceuticals (emulsification and, Cannabis formulations |
| Proof of Concept Testing (application-oriented formulation and process capability tests withTesting | – | – | – | – | – |
| Formulation development (>1500 formulations, optimal process parameters)Engineering | – | – | – | – | – |
| Qualification support (FAT/SAT, IQ/OQ, validation-ready systems, documentedTesting | – | – | – | – | – |
| Service & maintenance (spare parts, preventive maintenance, repairs for ShearJet® and otherAssembly | – | – | – | – | – |
| Feed & Skid Systems (upstream/downstream process integration)Assembly | – | – | – | – | – |
4 Anlagen & Maschinen
| Machine | Manufacturer / model | Quantity | Working area | Year built | Site |
|---|---|---|---|---|---|
| Electro-hydraulic laboratory homogenizer | Dyhydromatics ShearJet® HL60 V2 | – | – | – | Maynard, MA, USA |
| Pneumatic benchtop homogenizer | Dyhydromatics ShearJet® PL300 | – | – | – | Maynard, MA, USA |
| Electro-hydraulic homogenizer (R&D & pilot) | Dyhydromatics ShearJet® HP350 V2 | – | – | – | Maynard, MA, USA |
| Electro-hydraulic homogenizer (pilot & production) | Dyhydromatics ShearJet® HP1200 V2 | – | – | – | Maynard, MA, USA |
Additional services
Reference customers
Quality and Qualification
For regulated manufacturing operations, Dyhydromatics offers qualification support with FAT/SAT, IQ/OQ, validation-ready systems and documented process control. All ShearJet® systems are manufactured and tested in Maynard, Massachusetts.
| Evidence | Maynard, MA, USA |
|---|---|
| FAT/SAT | |
| IQ/OQ | |
| Documented process control |
History
- 2015
Company founded (derived from "Celebrating 10 Years of Dyhydromatics", December 2025)
- 2025
10th company anniversary as well as introduction of the ShearJet® HL60 V2 in 110 VAC
- 2026
Launch of the new ShearJet® HP Series V2 homogenizers (HP350 V2, HP1200 V2) and appointment of Kendall Killgore as Chief Science Officer
- 2026
Presence of ShearJet® high-pressure homogenizers at INTERPHEX 2026 as well as recognition at MET-I-CON 2026