Manufacturer and supplier of HTS screening compounds, fragments, building blocks as well as custom synthesis and computational chemistry for drug discovery
Life Chemicals, Inc.
Niagara on the Lake (Canada) · Kyiv (Ukraine) · Burlington (Canada) · USA Stock · Germany (EU Stock)New on Amplifa
About Life Chemicals
Life Chemicals, Inc. is an internationally operating chemistry company with an integrated platform for early-stage drug discovery. The company produces and distributes more than 600,000 HTS screening compounds, 78,000 fragments for fragment-based drug discovery, 15,000 building blocks as well as more than 150 targeted and focused screening libraries. In addition, Life Chemicals offers custom synthesis of drug-like compounds on a multi-gram to multi-kilogram scale, route scouting, scale-up, preparative HPLC purification and computational chemistry services such as virtual screening, docking and QSAR modeling. Synthesis is carried out in Kyiv (Ukraine) on more than 2,000 m² of production space with more than 60 qualified chemists; the chromatography laboratory is certified according to ISO/IEC 17025:2019. Customers are pharmaceutical, biotech and agrochemical companies as well as universities and academic institutions worldwide. Founded in 2004 in Burlington, Ontario (Canada), with roots dating back to 1995, the company supplies customers in more than 50 countries from warehouses in the USA and Germany.
- Site
- L0S 1J0 Niagara on the Lake, ON
- Processes
- Custom synthesis of organic compounds (drug-like compounds, building blocks), Synthesis of HTS compounds and screening libraries, Route scouting and product scale-up, Preparative HPLC purification (mg to multi-hundred gram), NMR spectroscopy (¹H, ¹⁹F, ¹³C, ³¹P, 2D-NMR), Analytical chromatography (ISO/IEC 17025:2019 certified), Chiral chromatography / racemate separation (ee determination, ALP detection), HPLC-based high-throughput solubility measurements
- Materials
- Drug-like organic compounds, Building Blocks, Fluorinated fragment compounds, Organic and inorganic reagents, solvents, synthesis intermediates, HTS screening compounds, Fragments, Custom synthesis compounds, Reagents and solvents
- Certificates
- ISO/IEC 17025:2019, Purity >90% (NMR/LCMS)
- Founded
- 1995 (I.F.
- Industries
- Pharma, Biotech, Agrochemistry, Universities and academic institutions
- 01
Computational chemistry / library design
- 02
Organic synthesis (mg to multi-kg)
- 03
Preparative HPLC purification
- 04
Analytical quality control (NMR, LC-MS, HPLC)
- 05
Compound formatting (pre-plated sets, DMSO/dry)
- 06
Warehousing and worldwide delivery
Products and Processes
HTS screening compounds
More than 600,000 drug-like organic compounds for high-throughput screening, with purity >90% (NMR/LCMS).
Fragments
78,000 fragments including fluorinated compounds for ¹⁹F-NMR-based fragment screening.
Building Blocks
15,000 building blocks in stock as a basis for synthesis and SAR exploration.
Custom synthesis compounds
Drug-like compounds on a multi-gram to multi-kilogram scale including route scouting and scale-up.
Reagents and solvents
Organic and inorganic reagents, laboratory solvents and synthesis intermediates with quality control at every production stage.
Sites
Kyiv
UAProduction and research site (>2,000 m² production area, >2,500 m² total)
- Part weight / size
- mg to multi-kilogram
- Lot size
- mg to multi-hundred-gram (preparative HPLC)
- Materials
- HTS compounds, fragments, building blocks, custom synthesis
- Varian VNMRS 400 MHz NMR
- Agilent 1260 Infinity II HPLC
- Agilent 6545A QTOF/1260 UHPLC
- 2 Shimadzu LC-8A preparative HPLC
- 6 Teledyne Isco Combi-Flash RF
- Agilent 7820A GC/MS 5977B
- Biotage microwave synthesis station
- Paar autoclaves
- Genevac HT-4X Series II
- SCHOTT Titroline KF
- ATAGO POLAX-2L
- Shimadzu UV/Vis 200-900 nm
- Thermo -80°C ultra-low freezer ULT 185-5-V
- Integra Viaflo Voyager pipetting platform
- Perkin-Elmer Victor 3 microplate reader
- Biotek Epoch microplate spectrophotometer
Niagara on the Lake
CAHead office Life Chemicals, Inc.
Burlington
CAFounding site of Life Chemicals, Inc. (2004)
USA Stock
USWarehouse and distribution (Life Chemicals USA)
- Materials
- Pre-plated sets, building blocks
EU Stock (Germany)
DEWarehouse and distribution (Life Chemicals Europe)
- Materials
- Pre-plated sets, building blocks
Products and Services
Inside the production
Industries
Processes & technical limits
| Processes | Tolerance | Max. part | Weight | Lot size | Materials |
|---|---|---|---|---|---|
| Custom synthesis of organic compounds (drug-like compounds, building blocks)Chemistry/synthesis (no classic manufacturing process) | – | – | Multi-gram – Multi-kilogram | – | drug-like compounds, building blocks, combinatorial libraries |
| Synthesis of HTS compounds and screening librariesChemistry/synthesis | – | – | – | > 600,000 screening compounds in | organic synthesis products |
| Route scouting and product scale-upChemistry/synthesis | – | – | – | – | – |
| Preparative HPLC purification (mg to multi-hundred gram)Analytics/separation | – | – | Milligram – multi-hundred gram | – | organic compounds |
| NMR spectroscopy (¹H, ¹⁹F, ¹³C, ³¹P, 2D-NMR)Testing/analytics | Purity > 90% | – | – | Over 200 ¹H-NMR spectra/day | organic compounds |
| Analytical chromatography (ISO/IEC 17025:2019 certified)Testing/analytics | – | – | – | Over 500 samples/day | – |
| Chiral chromatography / racemate separation (ee determination, ALP detection)Testing/analytics | – | – | – | – | racemates, enantiomers |
| HPLC-based high-throughput solubility measurementsTesting/analytics | – | – | – | up to 384 samples/day | fragments, compounds |
| Karl Fischer titration (water determination)Testing/analytics | – | – | – | – | – |
| UV/Vis spectrophotometry (200-900 nm)Testing/analytics | – | – | – | – | – |
| Computational chemistry / cheminformatics (virtual screening, docking, QSAR, de novo design)Engineering | – | – | – | – | – |
| Microwave synthesisChemistry/synthesis | – | – | – | – | – |
| PhotochemistryChemistry/synthesis | – | – | – | – | – |
21 Anlagen & Maschinen
| Machine | Manufacturer / model | Quantity | Working area | Year built | Site |
|---|---|---|---|---|---|
| NMR spectrometer | Varian VNMRS 400 MHz (Oxford Instruments Magnet) | 1 | – | – | Kyiv |
| HPLC with diode array detector | Agilent 1260 Infinity II (G4212B) | – | – | – | Kyiv |
| HPLC with VWD + laser polarimeter + fraction collector | Agilent 1100, PDR-Chiral ALP, 1200 Fraction Collector (G1364C) | – | – | – | Kyiv |
| HPLC with DAD/FLD/ELSD | Agilent 1100/1200, Softa 1400 ELSD | – | – | – | Kyiv |
| Mass spectrometer | Agilent G6140 and G1956 (ESI) | – | – | – | Kyiv |
| QTOF mass spectrometer with UHPLC | Agilent 6545A QTOF / 1260 Infinity UHPLC | 1 | – | – | Kyiv |
| HPLC with diode array detector | HP 1090 | – | – | – | Kyiv |
| Preparative HPLC | Shimadzu LC-8A (UV detector) | 2 | – | – | Kyiv |
| Flash chromatography system | Teledyne Isco Combi-Flash RF (ELSD/UV) | 6 | – | – | Kyiv |
| GC/MS system | Agilent 7820A GC + 5977B SQ-MSD | 1 | – | – | Kyiv |
| Karl Fischer titrator | SCHOTT Instruments Titroline KF | – | – | – | Kyiv |
| Polarimeter | ATAGO POLAX-2L | – | – | – | Kyiv |
| Melting point analyzer | OptiMelt MPA100 | – | – | – | Kyiv |
| UV/Vis spectrophotometer | Shimadzu | – | 200-900 nm | – | Kyiv |
| Microwave synthesis station | Biotage | – | – | – | Kyiv |
| Autoclaves | Paar | – | – | – | Kyiv |
| Microplate reader | Perkin-Elmer Victor 3, 1420 Multilabel Counter | – | – | – | Kyiv |
| Microplate spectrophotometer | Biotek Epoch (Gen5) | – | – | – | Kyiv |
| Ultra-low freezer (-80°C) | Thermo Scientific ULT 185-5-V Benchtop | – | – | – | Kyiv |
| Vacuum evaporation system | Genevac HT-4X Series II | – | – | – | Kyiv |
| Electronic pipettes / sample preparation platform | Integra/Thermo Viaflo (Voyager) | – | – | – | Kyiv |
Additional services
Quality
Compound purity exceeds 90%, confirmed by LC-MS and/or 400 MHz NMR; spectra are provided upon request. The chromatography laboratory is certified according to ISO/IEC 17025:2019 and analyzes more than 500 samples per day.
| Evidence | Kyiv |
|---|---|
| ISO/IEC 17025:2019 | |
| Purity >90% (NMR/LCMS) |
History
- 1995
Founding of the R&D laboratory I.F. Lab in Kyiv by Dr. Volodymyr Fetyukhin
- 2004
Founding of Life Chemicals, Inc. in Burlington, Ontario, Canada as international headquarters
- 2022
Resumption of production and services at the Kyiv site after interruptions caused by the Russian war of aggression
- 2025
Over 2,300 customers, more than 3,000 orders and delivery to over 50 countries