Development and manufacture of freeze-drying systems for laboratory, pilot and cGMP production as well as rotary vacuum concentrators.
Martin Christ Gefriertrocknungsanlagen GmbH
Osterode am Harz (An der Unteren Söse 50)New on Amplifa
About Martin Christ
Martin Christ Gefriertrocknungsanlagen GmbH, based in Osterode am Harz, develops and manufactures freeze-drying systems (lyophilisation) for laboratory, pilot and pharmaceutical production. The product range comprises laboratory freeze dryers with ice condenser capacities of 2.5 to 24 kg per drying run, pilot systems of the Epsilon series (4–18 kg) and production systems of the Zeta and Epsilon series with ice condenser capacities of 20 to 500 kg and more per batch. For cGMP production, steam-sterilisable two-chamber systems with CIP/SIP, filter integrity testing, PAT tools (LyoCam, LyoCoN, WTMplus, MTMplus) and automatic loading and unloading systems are available; the loading systems are developed by the subsidiary Motus Engineering. The portfolio is complemented by rotary vacuum concentrators (RVC). Product-contacted components are made of stainless steel 1.4404/1.4435, sight elements of borosilicate glass or acrylic glass, and seals of PTFE. The systems are used inter alia in the pharmaceutical industry, biotechnology, diagnostics, animal health and research; sales are handled via worldwide sales partners.
- Site
- Osterode am Harz
- Processes
- Freeze-drying (lyophilisation) - laboratory, Freeze-drying (lyophilisation) - pilot, Freeze-drying (lyophilisation) - production, Vacuum concentration (rotary vacuum concentrators), Process consulting and training / application laboratory (lyophilisability testing, trial drying, Maintenance, calibration (GMP-compliant) and repair of freeze-drying systems, Modernisation (retrofits) of freeze-drying systems including refrigeration technology and controls, Design and manufacture of freeze-drying systems (laboratory, pilot, production)
- Materials
- Stainless steel, Teflon (PTFE), Borosilicate glass, Acrylic glass (PMMA), Stainless steel 1.4404, Stainless steel 1.4435
- Certificates
- Other (EcoVadis Bronze)
- Industries
- Pharmaceutical industry (cGMP production), Biotechnology, Diagnostics, Animal Health, Food, Research/Laboratory
- 01
Engineering and design
- 02
Manufacture of system components (stainless steel processing)
- 03
Assembly and control integration
- 04
Commissioning and qualification (IQ/OQ, FAT/SAT)
- 05
Service, maintenance and modernisation
Materials and Processes
Stainless steel 1.4404
Product-contacted shelf surfaces and chamber components in pilot and production systems.
Stainless steel 1.4435
For product-contacted components with increased requirements on corrosion resistance.
Teflon (PTFE)
Seals and wear-resistant product-contact components.
Borosilicate glass
Sight doors and observation windows for process visibility.
Acrylic glass (PMMA)
Acrylic glass doors of laboratory and pilot systems for viewing the drying process.
Locations
Osterode am Harz
DEHeadquarters, manufacturing and development
- Materials
- Stainless steel 1.4404/1.4435, PTFE, borosilicate glass, PMMA
- Laboratory freeze dryers Alpha/Beta/Gamma/Delta series
- Pilot systems Epsilon series
- Production systems Zeta and Epsilon series
- Rotary vacuum concentrators RVC
- Loading and unloading systems (LyoShuttle, Pusher)
- Application laboratory
- Automated high-bay warehouse for spare parts
Product Lines
Inside the production
Industries
Processes & technical limits
| Processes | Tolerance | Max. part | Weight | Lot size | Materials |
|---|---|---|---|---|---|
| Freeze-drying (lyophilisation) - laboratoryDrying | – | – | 2.5 kg per drying run – 24 kg per drying run | – | aqueous solutions, organic solvents |
| Freeze-drying (lyophilisation) - pilotDrying | – | – | 4 kg – 16 kg per drying run | – | pharmaceutical products in vials or product trays |
| Freeze-drying (lyophilisation) - productionDrying | – | – | 20 kg – 500 kg and more ice condenser capacity | – | pharmaceutical products, bulk goods, vials |
| Vacuum concentration (rotary vacuum concentrators)Drying | – | – | – | – | liquid products, Eppendorf caps, MTP formats, 500 ml round flasks |
| Process consulting and training / application laboratory (lyophilisability testing, trial dryingEngineering | – | – | – | – | – |
| Maintenance, calibration (GMP-compliant) and repair of freeze-drying systemsAssembly | – | – | – | – | – |
| Modernisation (retrofits) of freeze-drying systems including refrigeration technology and controlsAssembly | – | – | – | – | – |
11 Anlagen & Maschinen
| Machine | Manufacturer / model | Quantity | Working area | Year built | Site |
|---|---|---|---|---|---|
| Laboratory freeze dryer Alpha 1-2 LSCbasic | Martin Christ Alpha 1-2 LSCbasic | – | Ice condenser capacity 2.5 kg, condenser temperature -55 °C, up to 8 ports | – | – |
| Laboratory freeze dryer Alpha/Beta series | Martin Christ Alpha 1-4, Alpha 2-4, Alpha 3-4, Beta 1-8, Beta 2-8 (LSCbasic/LSCplus) | – | Ice condenser capacity 4-8 kg, temperatures -55 to -105 °C | – | – |
| Laboratory freeze dryer Gamma 2-16 LSCplus | Martin Christ Gamma 2-16 LSCplus | – | Ice condenser capacity 16 kg, -85 °C | – | – |
| Laboratory freeze dryer Delta 2-24 LSCplus | Martin Christ Delta 2-24 LSCplus | – | Ice condenser capacity 24 kg, -85 °C | – | – |
| Laboratory freeze dryer MultiPort System | Martin Christ MultiPort System | – | Drying rack with 42 ports, ice condenser capacity 24 kg, -85 °C | – | – |
| Pilot freeze dryer Epsilon series | Martin Christ Epsilon 1-4 / 2-4 / 2-6D / 2-10D / 2-12D / 2-16D / 2-18D LSCplus, Solvent | – | Ice condenser capacity 4-18 kg, shelf area 0.07-1.51 m², -75 to -88 °C | – | – |
| Production freeze dryer Zeta series (Pharma Concept, vial drying, cGMP, steam-sterilisable) | Martin Christ Zeta-1 to Zeta-13 | – | Shelf area 1.1-13 m², ice capacity 12-141 kg, vials 2R-50H | – | – |
| Production freeze dryer Epsilon two-chamber systems (Multi Concept) | Martin Christ Epsilon 2-25D to 2-220D | – | Shelf area 0.27-17.28 m², ice capacity 25-220 kg | – | – |
| Production freeze dryer Epsilon single-chamber systems (Non-Sterile Concept, bulk) | Martin Christ Epsilon 2-40 / 2-60 / 2-90 / 2-220 | – | Shelf area 3.6-15.12 m², ice capacity 40-220 kg, condenser temperature -75 °C | – | – |
| Rotary vacuum concentrator (RVC) | Martin Christ RVC 2-18 / 2-25 / 2-33 CDplus (including HCl-resistant and IR-heated) | – | – | – | – |
| Automatic loading and unloading systems (LyoShuttle robots, pusher systems, frame loading) | Martin Christ / Motus Engineering LyoShuttle, pusher systems | – | Pusher up to 600 vials/min | – | – |
Additional services
Quality
Systems for cGMP production feature CIP/SIP cleaning and sterilisation, filter integrity testing (FIT) and PAT tools for process monitoring; maintenance and calibration are performed in accordance with GMP using certified measuring instruments. Qualification documentation (IQ, OQ, FAT, SAT, change controls) is prepared on a project-specific basis.
| Evidence | Osterode am Harz |
|---|---|
| Other (EcoVadis Bronze) |
History
- ca. 1947
More than 75 years of experience in freeze-drying; over 30,000 freeze dryers delivered.
- 2009
Among the first manufacturers worldwide to switch to flammable refrigerants.
- 2024
Laboratory and pilot systems fully converted to natural (flammable) refrigerants.
- 2025
First double materiality analysis completed.