Contract synthesis and click chemistry reagents for the early phase of drug development.
Sirius Fine Chemicals SiChem GmbH
28359 BremenNew on Amplifa
About SiChem
Sirius Fine Chemicals SiChem GmbH, based in Bremen, offers contract synthesis and click chemistry reagents for the early phase of drug development, serving in particular customers from the pharmaceutical, chemical and biotech sectors. Its range of services includes custom synthesis of PROTACs, linker systems and E3 ligand-linker conjugates as well as synthesis development for preclinical and early clinical phases. Based on expertise in click chemistry and PEG linker chemistry, the company also produces functionalized PEG linkers, lipids, artificial amino acids, active esters and clickable dyes. A particular focus lies on prodrugs whose active ingredient is only released in the organism, among other things through click reactions at the site of action. SiChem has extended its range of services to include GMP-compliant manufacturing and purification of pharmaceutical intermediates and active pharmaceutical ingredients; its GMP-certified infrastructure supports preclinical studies and early clinical development phases from synthesis development through to manufacturing from a single source. Customers include biotech companies, start-ups and research institutions.
- Site
- Bremen
- Processes
- Contract synthesis (custom synthesis), GMP-compliant manufacturing and purification of pharmaceutical intermediates and active ingredients, Click chemistry (bioorthogonal reactions), Synthesis development through to manufacturing from a single source (preclinical and early clinical, Click chemistry reagents, Synthesis development for preclinical and early clinical phases, PROTAC synthesis, linker systems, E3 ligand-linker conjugates, PEG linker chemistry
- Materials
- Pharmaceutical intermediates and active ingredients (API), PEG (polyethylene glycol) linkers, Lipids, Amino acids (artificial), Click reagents, PEG linkers, Dyes, Pharmaceutical active ingredients and intermediates
- Certificates
- GMP certification, ISO 9001, GMP
- Industries
- Pharmaceuticals, Chemicals, Biotech, Drug development/early phase
- 01
Synthesis development
- 02
Contract synthesis
- 03
Click chemistry reagents
- 04
GMP-compliant manufacturing
- 05
Purification
Product Groups and Chemistry
Click reagents
Click reagents such as artificial amino acids, active esters, alcohols and APIs for bioorthogonal reactions.
PEG linkers
Functionalized PEG linkers for click chemistry as well as for biotin and fluorescence labeling.
Lipids
(Functionalized) lipids and derivatives, among other things for studies of lipids in living cells.
Dyes
Clickable dyes with and without PEG linkers.
Pharmaceutical active ingredients and intermediates
GMP-compliantly manufactured and purified intermediates and active ingredients for preclinical and early clinical phases.
PROTACs and linker conjugates
Custom synthesis of PROTACs, linker systems and E3 ligand-linker conjugates.
Inositol phosphates
Free, membrane-permeable and/or photoactivatable inositol phosphate derivatives.
Locations
Bremen
DEHeadquarters
Inside the production
Industries
Processes & technical limits
| Processes | Tolerance | Max. part | Weight | Lot size | Materials |
|---|---|---|---|---|---|
| Contract synthesis (custom synthesis)Chemical synthesis | – | – | – | – | pharmaceutical intermediates, active ingredients (API), PROTACs, linker systems, E3 ligand-linker conjugates, PEG linkers, lipids |
| GMP-compliant manufacturing and purification of pharmaceutical intermediates and active ingredientsChemical synthesis | – | – | – | – | pharmaceutical intermediates, active ingredients (API) |
| Click chemistry (bioorthogonal reactions)Chemical synthesis | – | – | – | – | click reagents, artificial amino acids, active esters, PEG linkers, dyes, lipids |
| Synthesis development through to manufacturing from a single source (preclinical and early clinicalChemical synthesis | – | – | – | – | active ingredients, intermediates |
Additional services
Quality
SiChem manufactures and purifies pharmaceutical intermediates and active ingredients in compliance with GMP; the infrastructure used for this is GMP-certified. An ISO-9001 certificate is displayed on the company website.
| Evidence | Bremen |
|---|---|
| ISO 9001 | |
| GMP |
History
25 years of SiChem – anniversary; no specific year of foundation is given.
- 2025
Documented milestone: click chemistry in cancer therapy.
- 2026
Expansion of the range of services to include GMP-compliant manufacturing of pharmaceutical intermediates and active ingredients.