Automated capsule synthesizers for organic synthesis in pharma, biotech and research.
Synple Chem AG
Kemptthal (CH)New on Amplifa
About Synple Chem
Synple Chem is a spin-off of ETH Zurich founded in 2016, headquartered in Kemptthal (Switzerland). The company develops and manufactures automated synthesizers for organic chemistry that work on the principle of a coffee capsule machine: starting material and a single-use reagent capsule are loaded, and the machine handles reaction, work-up and purification fully automatically. The portfolio includes the compact capsule-based synthesizer Synple 2 (footprint 25 x 35 cm), the Synple 1, and the flexible parallel synthesizer Synple Unity. In addition, Synple Chem offers reagent cartridges for eight reaction classes with over 40 reagents, reaction kits, and with Synple 4.0 a solution for the synthesis of hits from virtual libraries. Customers come from pharma, biotech, CROs and academic research and are located in Europe, the USA and Asia. The team is continuously developing new reaction classes to accelerate discovery research.
- Site
- Kemptthal
- Processes
- Automated organic synthesis (reaction, work-up and purification fully automated), Automated cleaning sequence / washing sequence after synthesis, Parallel synthesis (Synple Unity, flexible parallel synthesizer), Synthesis of compound libraries (Library Generation), PROTAC synthesis (case study), Automated organic synthesis (Synple 2, Synple 1, Synple Unity), Reagent cartridges/capsules, Reaction kits
- Materials
- Synple 2 – Capsule-based synthesizer, Synple 1 – Automatic synthesizer, Synple Unity – Parallel synthesizer, Synple 4.0 – Virtual libraries, Reagent cartridges, Synple Reaction Kits
- Certificates
- Encapsulated reaction chamber (user protection), Automated cleaning sequence without contamination risk
- Founded
- 2016
- Industries
- Pharma, Biotech, CROs, Academic research
- 01
Idea and machine development (R&D)
- 02
Manufacturing of the synthesizers
- 03
Production of reagent cartridges and kits
- 04
Software (Synple 4.0, virtual libraries)
- 05
Application Notes, training and support
Reaction Classes & Cartridges
Synple 2 – Capsule-based synthesizer
Compact automatic synthesizer with a footprint of 25 x 35 cm for reaction, work-up and purification at the push of a button.
Synple 1 – Automatic synthesizer
First generation of the automated synthesis platform.
Synple Unity – Parallel synthesizer
Flexible parallel synthesizer for simultaneous syntheses.
Synple 4.0 – Virtual libraries
Connecting automated synthesis with digital chemical space for rapid hit screening.
Reagent cartridges
Single-use capsules with a scanned chip for eight reaction classes with over 40 reagents.
Synple Reaction Kits
Reaction kits to complement the cartridge chemistry.
Locations
Kemptthal
CHHeadquarters, development and production
- Synple 1
- Synple 2
- Synple Unity
Devices & Components
Inside the production
Industries
Processes & technical limits
| Processes | Tolerance | Max. part | Weight | Lot size | Materials |
|---|---|---|---|---|---|
| Automated organic synthesis (reaction, work-up and purification fully automated) | – | – | – | – | – |
| Automated cleaning sequence / washing sequence after synthesis | – | – | – | – | – |
| Parallel synthesis (Synple Unity, flexible parallel synthesizer) | – | – | – | – | – |
| Synthesis of compound libraries (Library Generation) | – | – | – | – | – |
| PROTAC synthesis (case study) | – | – | – | – | – |
3 Anlagen & Maschinen
| Machine | Manufacturer / model | Quantity | Working area | Year built | Site |
|---|---|---|---|---|---|
| Automatic capsule-based synthesizer | Synple Chem Synple 2 | – | Footprint 25 x 35 cm | – | Kemptthal, Switzerland |
| Flexible parallel synthesizer | Synple Chem Synple Unity | – | – | – | Kemptthal, Switzerland |
| Automatic synthesizer | Synple Chem Synple 1 | – | – | – | Kemptthal, Switzerland |
Additional services
Reference customers
Quality & Safety
The reaction chamber of the automatic synthesizer is fully encapsulated, so users have no contact with chemicals – in accordance with current laboratory safety standards. Standardized, fully automated processes ensure reproducible results.
| Evidence | Kemptthal |
|---|---|
| Encapsulated reaction chamber (user protection) | |
| Automated cleaning sequence without contamination risk |
Company History
- 2015
Idea for the concept of a 'coffee machine for chemistry' in the Bode group at ETH Zurich; start of machine development by Benedikt Wanner
- 2016
Founding of Synple Chem as an ETH Zurich spin-off, seed investment, beta version tested with customers from pharma, biotech, CROs and academia
Launch of a new machine version and expansion with numerous reaction classes; introduction of the parallel synthesizer Synple Unity and Synple 4.0 for virtual libraries