Specialist in radiosynthesizers and lab automation for the automated production of PET tracers
Synthra GmbH
Hamburg (Albert-Einstein-Ring 21, 22761)New on Amplifa
About Synthra
Synthra GmbH, based in Hamburg, is a specialized manufacturer of radiosynthesizers and laboratory automation solutions for the production of molecular imaging tracers. The portfolio covers modules for 11C and 18F radiotracers as well as other radioisotopes such as 13N and 68Ga, including synthesizers for [18F]FDG, [18F]FDopa, [11C]Methionine and [11C]Choline, individually customized modules, targetry systems and HPLC equipment for purification and quality control. A unique feature is the integrated, fully automatic self-cleaning system, which flushes the system after every run without opening the hot cell and minimizes contaminated waste. In addition to development and manufacturing, the company offers installation, on-site application training, technical support for targetry, tracer production and quality control, as well as maintenance and spare parts. Founder Dr. Bruno Nebeling is regarded as a pioneer of automated production of imaging tracers; customers in radiopharmacy, nuclear medicine and the pharmaceutical industry are located worldwide.
- Site
- Hamburg
- Processes
- Manufacture of radiosynthesizers for PET tracer automation, Automated production of molecular imaging tracers (11C and 18F radiotracers), HPLC equipment for purification and quality control, Targetry (target/target systems for radionuclide production), Customized radiosynthesizer modules, Quality control of radiopharmaceuticals, Lab automation, On-site application training for tracer production
- Materials
- Carbon-11 (11C radioisotope), Fluorine-18 (18F radioisotope), Nitrogen-13 (13N radioisotope), Gallium-68 (68Ga radioisotope)
- Founded
- 2008
- Employees
- 2–10
- Industries
- Radiopharmacy, Nuclear Medicine, PET/Molecular Imaging, Lab Automation, Pharmaceutical Industry
- 01
Engineering & design of the synthesis modules
- 02
Manufacturing and assembly of the radiosynthesizers
- 03
Installation in the customer's hot cell
- 04
On-site Application Training
- 05
Technical support, maintenance and spare parts
- 06
HPLC quality control (radiochromatography)
Isotopes & Processes
Carbon-11 (11C radioisotope)
Basis for synthesis modules such as MeIplus, Methionine/Choline, C11 Acetate and HCNplus.
Fluorine-18 (18F radioisotope)
Used in modules such as RNplus, FDGtwo and F-Dopa for nucleophilic and electrophilic substitution.
Nitrogen-13 (13N radioisotope)
Covered by the N13/NaF module.
Gallium-68 (68Ga radioisotope)
Processed in the metal chelate modules MChelate and MChelateplus.
Location
Hamburg
DEHeadquarters / Production
- Materials
- 11C, 18F, 13N and 68Ga modules
- Radiosynthesizers MeI, MeIplus, MeIplus Research, MeIplus Reaction Loop
- Radiosynthesizers Methionine/Choline, C11 Acetate, HCNplus
- Radiosynthesizers RNplus, RNplus Research, FDGtwo, F-Dopa
- Radiosynthesizers N13/NaF, MChelate, MChelateplus
- Radiochromatography systems RadChromplus (isocratic and quaternary)
Industries
Processes & technical limits
| Processes | Tolerance | Max. part | Weight | Lot size | Materials |
|---|---|---|---|---|---|
| Manufacture of radiosynthesizers for PET tracer automationEngineering | – | – | – | – | – |
| Automated production of molecular imaging tracers (11C and 18F radiotracers)Engineering | – | – | – | – | [11C]Methionine, [11C]Choline, [11C]DASB, [11C]Raclopride, [18F]FDopa, [18F]FDG, [18F]FLT, [18F]FMiso |
| HPLC equipment for purification and quality controlTesting | – | – | – | – | – |
| Targetry (target/target systems for radionuclide production)Engineering | – | – | – | – | – |
| Customized radiosynthesizer modulesEngineering | – | – | – | – | – |
| Quality control of radiopharmaceuticalsTesting | – | – | – | – | – |
| Lab automationEngineering | – | – | – | – | – |
| On-site application training for tracer productionEngineering | – | – | – | – | – |
| Self-cleaning system for radiosynthesizersEngineering | – | – | – | – | – |
16 Anlagen & Maschinen
| Machine | Manufacturer / model | Quantity | Working area | Year built | Site |
|---|---|---|---|---|---|
| Radiosynthesizer (11C methylation) | Synthra MeI | – | – | – | Hamburg |
| Radiosynthesizer (11C methylation) | Synthra MeIplus | – | – | – | Hamburg |
| Radiosynthesizer (11C research module) | Synthra MeIplus Research | – | – | – | Hamburg |
| Radiosynthesizer (11C reaction loop) | Synthra MeIplus Reaction Loop | – | – | – | Hamburg |
| Radiosynthesizer ([11C]Methionine/[11C]Choline) | Synthra Methionine/Choline | – | – | – | Hamburg |
| Radiosynthesizer (C11 Acetate) | Synthra C11 Acetate | – | – | – | Hamburg |
| Radiosynthesizer (HCN) | Synthra HCNplus | – | – | – | Hamburg |
| Radiosynthesizer (18F nucleophilic) | Synthra RNplus | – | – | – | Hamburg |
| Radiosynthesizer (18F nucleophilic, research) | Synthra RNplus Research | – | – | – | Hamburg |
| Radiosynthesizer ([18F]FDG) | Synthra FDGtwo | – | – | – | Hamburg |
| Radiosynthesizer ([18F]FDopa) | Synthra F-Dopa | – | – | – | Hamburg |
| Radiosynthesizer (N13/NaF) | Synthra N13/NaF | – | – | – | Hamburg |
| Radiosynthesizer (metal chelates) | Synthra MChelate | – | – | – | Hamburg |
| Radiosynthesizer (metal chelates) | Synthra MChelateplus | – | – | – | Hamburg |
| Radiochromatography system (quality control, isocratic) | Synthra RadChromplus - Isocratic version | – | – | – | Hamburg |
| Radiochromatography system (quality control, quaternary) | Synthra RadChromplus - Quaternary version | – | – | – | Hamburg |
Additional services
History
- 2008
Foundation of Synthra GmbH in Hamburg by Dr. Bruno Nebeling, a pioneer of automated production of molecular imaging tracers.