Development, scale-up and contract manufacturing of chemical syntheses from the milligram range up to multi-kilogram and tonne volumes
Trigona GmbH
Wiesbaden (Kalle-Albert Industrial Park), GermanyNew on Amplifa
About Trigona
Trigona GmbH is an independent, mid-sized development partner for chemical synthesis, based in the Kalle-Albert Industrial Park in Wiesbaden. The company was founded in 2000 by Dr. Günter Krummel and Dr. Peter Schade and operates as a specialist for kg-scale syntheses, filling the gap between laboratory research on the gram scale and tonne-scale production. The portfolio covers synthesis development and route scouting, scale-up and pilot production, toll and contract manufacturing, as well as analytics and quality assurance for organic and inorganic chemistry, polymer chemistry and specialty chemistry. Trigona has three laboratories, three explosion-proof reactor systems and an analytical laboratory; reactions are possible from the milligram to multi-kilogram scale in the temperature range -100 °C to +200 °C. A dedicated production plant manufactures macromonomers on a multi-tonne scale under BImSchG (Federal Immission Control Act) permitting and GMP-compliant conditions. The quality management system is certified to ISO 9001:2015.
- Site
- Wiesbaden
- Processes
- Synthesis development & route scouting, Scale-up & pilot production, Toll and contract manufacturing (small and medium batches), Production of mixtures and dilutions, Repackaging of chemicals into smaller containers, Purification of substances, Analytics: substance analysis by NMR spectroscopy, Analytics: analytical HPLC
- Materials
- organic chemicals, inorganic chemicals, Polymers / polymer materials (incl. photoinduced polymers), Macromonomers, Specialty chemicals, Pharmaceutical chemicals, Agrochemicals, Fine chemicals
- Certificates
- ISO 9001:2015, ISO 9001:2015 (TÜV SÜD, no. 12 100 64138), GMP-compliant structures (upon agreement), BImSchG permit (macromonomer/membrane production)
- Founded
- 2000
- Industries
- Pharmaceuticals, Specialty chemistry, Agrochemistry, Electronic materials, Polymers, Medical technology
- 01
Synthesis development & route scouting
- 02
Raw material procurement
- 03
Scale-up & pilot production
- 04
Toll and contract manufacturing
- 05
Cleaning, mixing, dilution, repackaging
- 06
Analytics & quality assurance
- 07
Documentation & shipping
Materials & Processes
Organic chemicals
The basis of contract and multi-step syntheses up to the multi-kilogram scale.
Inorganic chemicals
Part of the synthesis portfolio alongside organic chemistry.
Polymers (incl. photoinduced polymers)
Customer production on multi-purpose systems, including for electronic materials.
Macromonomers
Multi-tonne production on a dedicated plant under BImSchG permitting and GMP-compliant conditions.
Fine chemicals & specialty chemicals
Focus of contract synthesis and process development.
Pharmaceutical and agrochemicals
Custom synthesis of intermediates and end products.
Raw materials for OLED production
Many years of production on multi-purpose systems.
Membrane materials
Production with BImSchG permitting.
Locations
Wiesbaden
DEHeadquarters, laboratories, production, analytics
- Part weight / size
- mg to multi-kg, dedicated plant up to 30 t/year
- Lot size
- mg/g to multi-kg batches, multi-tonne (dedicated plant)
- Materials
- Organic/inorganic chemicals, polymers, macromonomers, fine chemicals
- Gram laboratory
- Kilogram laboratory
- Analytical laboratory
- 3 Ex reactor systems
- Multipurpose reactors 63 L and 250 L
- Dedicated macromonomer production plant (30 t p.a., BImSchG)
- Multi-purpose systems
- NMR spectrometer
- Analytical HPLC
- UV/VIS spectrometer
- DSC
- Karl Fischer coulometer
- Titrators
- Viscometers
Products & Components
Inside the production
Industries
Processes & technical limits
| Processes | Tolerance | Max. part | Weight | Lot size | Materials |
|---|---|---|---|---|---|
| Synthesis development & route scoutingChemical synthesis | – | – | – | – | organic chemistry, inorganic chemistry, polymer chemistry, specialty chemistry |
| Scale-up & pilot productionChemical synthesis | – | – | – | – | organic substances, fine chemicals |
| Toll and contract manufacturing (small and medium batches)Chemical synthesis | – | – | – | – | macromonomers, membrane materials, substances for surface coatings, raw materials for OLED production |
| Production of mixtures and dilutionsChemical synthesis | – | – | – | – | chemicals |
| Repackaging of chemicals into smaller containersChemical synthesis | – | – | – | – | chemicals |
| Purification of substancesChemical synthesis | – | – | – | – | – |
| Analytics: substance analysis by NMR spectroscopyAnalytics & Quality | – | – | – | – | – |
| Analytics: analytical HPLCAnalytics & Quality | – | – | – | – | – |
| Analytics: UV/VIS spectrometryAnalytics & Quality | – | – | – | – | – |
| Analytics: viscosity measurement (viscometer)Analytics & Quality | – | – | – | – | – |
| Analytics: differential scanning calorimetry (DSC)Analytics & Quality | – | – | – | – | – |
| Analytics: Karl Fischer coulometry (water determination)Analytics & Quality | – | – | – | – | – |
| Analytics: titration (titrators)Analytics & Quality | – | – | – | – | – |
| Reaction monitoring during synthesis / reaction kineticsAnalytics & Quality | – | – | – | – | – |
| Method development, validation and qualification (GMP-compliant upon agreement)Analytics & Quality | – | – | – | – | – |
| Incoming inspections of raw materials / quality inspections of products (external partner service)Analytics & Quality | – | – | – | – | – |
| Structure elucidation by combined NMR and substance analysisAnalytics & Quality | – | – | – | – | – |
| Planning and realization of chemical machinery and small plantsPlant engineering / Technical department | – | – | – | – | – |
| Chemical synthesis in the temperature range -100°C to +200°C (mg to multi-kg)Chemical synthesis | – | – | – | – | organic & inorganic chemicals, polymers, specialty chemicals |
14 Anlagen & Maschinen
| Machine | Manufacturer / model | Quantity | Working area | Year built | Site |
|---|---|---|---|---|---|
| Multipurpose reactor | – | – | – | – | – |
| Multipurpose reactor | – | – | – | – | – |
| Ex reactor system (explosion-proof system) | – | – | – | – | – |
| Laboratory | – | – | – | – | – |
| Laboratory | – | – | – | – | – |
| NMR spectrometer | – | – | – | – | – |
| Analytical HPLC | – | – | – | – | – |
| UV/VIS spectrometer | – | – | – | – | – |
| Viscometer | – | – | – | – | – |
| Differential scanning calorimeter (DSC) | – | – | – | – | – |
| Karl Fischer coulometer | – | – | – | – | – |
| Titrators | – | – | – | – | – |
| Dedicated production plant (macromonomer) | – | – | – | – | – |
| Multi-purpose systems | – | – | – | – | – |
Additional services
Quality
Analytics and quality assurance are carried out under ISO 9001; all products are delivered with a certificate of analysis. In-house equipment includes NMR spectrometers, HPLC, UV/VIS, DSC, Karl Fischer coulometry and titration; GMP-compliant structures are possible upon agreement.
| Evidence | Wiesbaden |
|---|---|
| ISO 9001:2015 (TÜV SÜD, no. 12 100 64138) | |
| GMP-compliant structures (upon agreement) | |
| BImSchG permit (macromonomer/membrane production) |
History
- 2000
Founded as Trigona oHG by Dr. Günter Krummel and Dr. Peter Schade
- 2013
Converted into Trigona GmbH
- 2023
Management handed over to Sarah Schade (next generation)